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Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma

We propose an approach to detection of essential genes/proteins required for cancer cell survival. A gene is considered essential if a mutation with high impact upon the function of encoded protein causes death of the cancer cell. We draw an analogy between essential cancer proteins and well-known Abraham Wald's work on estimating the plane critical areas using data on survivability of aircraft...

Bringing Down Cancer Aircraft: Searching For Essential Hypomutated Proteins In Skin Melanoma Authors

Background We propose an approach to detection of essential proteins required for cancer cell survival. Gene is considered essential if mutation with high functional impact upon function of encoded protein causes death of cancer cell. We draw an analogy between essential cancer proteins and well-known Abraham Wald’s work on estimating the plane critical areas using data on survivability of airc...

Aircraft landing problems with aircraft classes

This paper focuses on the aircraft landing problem that is to assign landing times to aircraft approaching the airport under consideration. Each aircraft’s landing time must be in a time interval encompassing a target landing time. If the actual landing time deviates from the target landing time additional costs occur which depend on the amount of earliness and lateness, respectively. The objec...

Steady Aircraft Flight and Aircraft Performance

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